Engineering disease models to study host-microbe interactions
In the Porras Tissue-Microbe Interactions Lab, we study interactions between humans and microorganisms that drive tissue remodeling.
Led by Dr. Ana Maria Porras, our lab is dedicated to unraveling the mechanisms by which microbes regulate human health and disease. We seek to understand how microorganisms reshape the host extracellular matrix, the complex network that surrounds all cells in human tissues. We focus primarily on the microbiome and tropical parasitic diseases, with a special interest in human-microbe interactions that have significant implications for populations in the Global South.
We use a multidisciplinary strategy to explore the relationships between microorganisms and human tissues.
We leverage microscopy, bioinformatics, and molecular biology to characterize the tissue remodeling that occurs as a direct result of human-microbe interactions. In parallel, we design both in vitro and in vivo models that more closely reflect healthy and diseased tissue biology. These engineered platforms allow us to identify the mechanisms through which “beneficial” and pathogenic microorganisms drive disease processes in the human host.
We value working across disciplines, backgrounds, and borders to approach scientific questions from multiple angles and spark innovation.
We approach research questions with an open mind, willing to dive into unexplored areas, and seeking to increase participation in the scientific process - locally and globally. We also believe in the power of art and science communication to engage communities and ignite curiosity.
We follow four central principles:
To do quality science
To develop each lab member to become a successful scientist and reach their personal goals
To build an open, welcoming, supportive, and intellectually stimulating environment
